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讲准字366号:钴催化的自由基C-H官能团化反应

发布时间:2017-11-30|浏览次数:

题目:钴催化的自由基C-H官能团化反应

主讲:陆红健

时间:2017年12月8日 15:30

地点:化学化工学院212报告厅

主办:化学化工学院


主讲简介:陆红健,南京大学教授。研究专长:手性卟啉的合成及其不对称催化反应研究。陆红健,2012年度“江苏省特聘教授”。1977年生于江苏启东,2001年毕业于中国科学技术大学高分子化学系,2006年毕业于中国科学院上海有机化学研究所,获得博士学位(导师:李超忠教授)。2007年在美国南佛罗里达大学(University of South Folrida)化学系从事博士后研究工作(手性卟啉的合成及其不对称催化反应研究,导师: Peter X. Zhang), 2012年,南京大学化学化工学院、化学与生物医药科学研究所副教授。

主讲内容:C−H functionalization processes can significantly simplify the synthesis of pharmaceuticals, natural products, agrochemicals, polymers, and feedstock commodity chemicals. Therefore, transition-metal-catalyzed C−H functionalization has achieved considerable advances and been use as an increasingly viable toolbox for selective C−C and C−X bond-forming reactions. The majority of catalyzed C−H functionalization was achieved employing precious second- and third-row transition metals. The development of catalysts based on the naturally more abundant and, hence, cost-efficient 3d transition metal complexes, represents an attractive alternative. My laboratory has been in the process of radicals involved cobalt catalyzed C-H functionalization. One example is that cobalt(II) porphyrin complexes ([Co(Por)]) catalyzed radical C(sp3)–H amination. It possesses uncommon capability for efficient amination of challenging primary and electro-deficient C–H bonds and exhibits remarkable chemoselectivity toward allylic and propargylic C–H amination reactions. Another example is that cobalt catalyzed radical C(sp2)-H functionalization. Different carbon radicals have been utilized as efficient coupling reagents, presenting a general method for functionalizing aromatic compounds.


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